To develop a cloud ready application is only one side of a medal, the other side is the cloud environment hosting this application. As a software architect you have to make some decisions giving a consideration to your target runtime environment. Some aspects like configuration, fault tolerance, health checks, application metrics, request tracing and service discovery have a strong coupling with the cloud environment. Eclipse MicroProfile has a lot of specifications to make your Jakarta EE based application ready for the cloud. Istio is an open platform sitting on top of Kubernetes with sometimes similar functionalities. Starting with a short introduction of Istio and MicroProfile, this session will show you how you can combine these two worlds to get the best of it.